High Purity CO2 for Supercritical Fluid Chromatography (SFC)
Ultra-low impurity CO2 for clean baselines, accurate separations, and extended column life in SFC and SCFC systems.
Order SFC-Grade CO2 Request Certificate of Analysis
What is SFC?
Supercritical Fluid Chromatography (SFC) uses carbon dioxide above its critical state (temperature >31.1°C and pressure >73.8 bar) as the primary mobile phase. In this state, CO2 combines the solvating power of a liquid with the diffusivity and low viscosity of a gas — enabling faster, more efficient separations than traditional HPLC.
Any impurities in the CO2 directly affect baseline noise, peak shape, and detector response. This is why ultra-high purity CO2 is essential for reliable SFC results.
Why CO2 Purity Matters in SFC
Clean Baselines
Low hydrocarbon content eliminates ghost peaks and baseline drift, giving you cleaner chromatograms and more accurate quantitation.
Column & Pump Protection
Moisture and particulates cause premature wear of high-pressure pumps and expensive columns. Ultra-pure CO2 extends equipment life significantly.
Reproducible Results
Consistent purity batch-to-batch ensures your analytical results are reproducible and compliant with regulatory standards.
SFC Applications
| Application | Description |
|---|---|
| Chiral Separations | SFC is the method of choice for separating enantiomers in pharmaceutical development and quality control. |
| Pharmaceutical QC | Detection of impurities, degradants, and chiral purity in drug substances and products. |
| Natural Products | Analysis and purification of low to moderate molecular weight, thermally labile compounds. |
| Preparative Purification | Large-scale purification with easy solvent removal — CO2 simply evaporates at ambient pressure. |
| Food & Flavour Analysis | Analysis of fats, oils, vitamins, and flavour compounds using green chemistry methods. |
Why Choose CO2 for Chromatography?
- Non-flammable & non-toxic — safer than organic solvents
- High diffusivity — 3-10x faster separations than HPLC
- Low viscosity — lower back-pressure, longer column life
- Excellent solvating power — tuneable with pressure and co-solvents
- Green chemistry — reduces organic solvent consumption by up to 90%
- Easy solvent removal — CO2 evaporates at ambient pressure
- Low cost — high purity CO2 is economical compared to HPLC solvents
- Batch certified — Certificate of Analysis with every delivery
Power Your SFC with Sicgil's Ultra-Pure CO2
Available in small cylinders for R&D labs to manifold systems for high-throughput facilities.
Order SFC-Grade CO2 Request Certificate of Analysis